Investigational Treatments Now
Concierge access to promising immuno-oncology treatments for patients with no time to lose.
What is PrincipledRx?
Concierge service for access to investigational cancer treatments, supporting patients and physicians with transparent, legally permitted care outside the traditional system.
Ethical & Legal
We operate Right to Try programs in sovereign Native American Indian Zones.
Physician-Centered
We empower doctors with a legal pathway to advanced care for their patients.
Treatment-Focused
Our focus is on accessing advanced immuno-oncology therapies for patients.
The Principled Approach
From referral to treatment — how our process works
Step 1:
Submit a Case
Starts with intake form submitted by a physician, advocate, or patient.
Step 2:
Eligibility
Our clinical partners assess the patient’s situation to determine fit for program.
Step 3:
Access Care
Care is arranged through a licensed clinic within a sovereign medical zone.
Step 4:
Follow Up
We coordinate logistics and stay involved alongside the referring physician.
Safer for Doctors.
Better for Patients.
Our Program Protects Doctors
Physician Protection
FDA-recognized Right to Try program in Native American Indian sovereign-zones, greatly reducing tort exposure.
Legal Legitimacy
Participating oncologists can stay involved—and even receive compensation—so you maintain continuity of care.
Patient Convenience
Sovereign Indian Zone clinics based in the the U.S. makes repeat treatments logistically viable for your patients.
Elevated Experience
High-end lodging, private transportation, and dedicated support ensure patients are cared for with dignity.
PrincipledRx provides access to Agenus’s investigational therapy
Botensilimab (BOT) and balstilimab (BAL) are in clinical trials under an active IND. This combo has cleared Phase 1 safety testing and is being studied in advanced cancer patients.
Note: BOT/BAL is investigational and not FDA-approved.
Reported Outcomes to Date
Promising results in MSS colorectal cancer, where most immunotherapies fail
Median survival: 20.9 months in heavily pretreated patients without liver metastases
Potential to reduce chemo, radiation, and surgery in select cases
Learn more at https://agenusbio.com/
For Biotech & Pharma: Bring Your Therapy to Patients Who Need Options Now
If your therapy is under an active IND application, PrincipledRx offers a compliant, structured pathway to make it accessible through Right to Try — without relying on traditional trial infrastructure.
Why Partner With Us:
Access under federal Right to Try law, with no IRB or clinical trial enrollment required.
Delivered through sovereign jurisdictions to reduce regulatory exposure and protect participating entities.
Reinforces your mission and investor value by ethically extending access to patients seeking investigational care.
Our work reflects a simple truth: care should be guided by conscience, not constraints.
Integrity
Built for doctors who practice medicine with conviction.
Autonomy
Patients and physicians deserve the right to choose.
Dignity
Every life deserves care that is personal, human, and hopeful.
Safety
We protect all parties — legally and logistically.
Trust
We build relationships, not transactions.
